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The Bacille-Calmette-Guérin (BCG) vaccine, developed almost 100 years ago, has been shown to prevent severe forms of TB in children, and is widely used though coverage varies.1
However, the vaccine is not effective after early childhood and there is currently no vaccine that is effective in preventing TB in adults. We urgently need more effective vaccines to fight TB.1
TB is very difficult to diagnose in children, and few medicines are available in paediatric formulations, forcing physicians to crush or split the adult pills to adjust the doses.
Otsuka is one of the first companies to conduct clinical trials of medicines for multidrug-resistant TB (MDR-TB) in children. Trials are completed testing the safety and efficacy of an MDR-TB medicine, including a fruit flavoured and water-soluble paediatric formulation.2
1. World Health Organization. Global Tuberculosis Report 2020. World Health Organization, Geneva, 2020. 2. ClinicalTrials.gov identifiers: NCT01856634 and NCT01859923 Information current as of 30-12-2020 Reference ONP-COP-2000001